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Furthermore, TLR4 knockout mice exhibited more severe EAE symptoms than wild-type mice, associated with increased priming of encephalitogenic Th17 cells (107)

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Haikala HM, Lopez T, Kohler J, Eser PO, Xu M, Zeng Q, et al

Finally, downregulation of the TCA cycle and glycolysis, which are components of energy metabolism, along with the decrease in ETC, showed that the intestinal epithelial cells were impaired in the supply of energy needed to cope with the stress caused by infection

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