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291,292 The activation of inflammation leads to cell damage, and eventually, the accumulation of damage accelerates aging

Veterinary Microbiol

Its crosstalk with VHL/HIF creates a positive feedback loop, where HIF-induced expression of growth factors activates PI3K/AKT pathway through RTKs

Its now widely used in both dermatology and trichology for improving skin texture, reducing wrinkles, and, most importantly for our discussion, revitalising hair follicles

Research has also suggested that exercise can reduce oxidative stress by increasing glutathione levels

10.1080/10826068.2025.2457539 67 LiY.HaoY.YangX.ZhaoJ.ChangR.WangB.et al (2025b)