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2 Overview of circadian machinery and clock associated ubiquitination 2.1 The Drosophila circadian clock Much of the foundational knowledge of circadian biology came from Drosophila melanogaster

Over the 8 residues spanning P4 to P4, it has 7 of 8 identical to the M pro site at the nsp12/nsp13 junction, with the only mismatch at the highly variable P3 position (Figure 1D), giving a near-perfect match to the M pro consensus

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