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Methods A systematic literature search was conducted in PubMed and Google Scholar databases until July 2025

In addition, ZnONPs displayed a significant influence on the cardiovascular system since they combat the rise in blood pressure and the pathological changes of the heart and aorta besides maintaining plasma nitric oxide levels

These transcription factors trigger EMT, converge at the promotion of E-cadherin repressors, and mediate phenotypic changes by downregulating epithelial traits while inducing mesenchymal characteristics (60)