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You can administer both compounds at caloric maintenance or surplus, but the metabolic shifts will be far less pronounced than in deficit states

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Response: We agree with the commenters' request for APC reassignment

Mild site reactions like redness or swelling are normal and typically resolve within 24 to 72 hours without intervention

The treatment involves a quick and relatively painless injection by a healthcare professional, typically taking only a few minutes

It has been suggested that physicians should consider screening for vitamin B 12 deficiency in diabetic patients before starting metformin therapy, and periodic monitoring of vitamin B 12 levels has been recommended for all patients using metformin, particularly for those using the medication long-term [21, 34]