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Montserrat M, de Gregorio E, de Dios C, Roca-Agujetas V, Cucarull B, Tutusaus A, Morales A, Colell A (2020) Mitochondrial glutathione: recent insights and role in disease

PMID: 101 SahinUTreci

Reiter and Tan (2019) proposed that melatonin exhibits its major protective effects on neurons at the level of mitochondria (Reiter and Tan, 2019)

[231] when triggered by amphetamine, this pathway activates Ras homolog A (RhoA) and its downstream protein kinase, Rho-associated coiled-coil kinase (ROCK), an effect that internalizes both DAT and the neuronal glutamate transporter EAAT3

Following TMZ and EP treatment, we observed a 13.4-15.7 % increase in non-stained live cells among U87-R cells compared to U87 cells, along with similar reductions of 15.05-17.91 % in Annexin V-positive (apoptotic) and Annexin V:PI-positive (late apoptotic) cells, confirming reduction of early and late apoptosis in the resistant U87-R population

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Almazroo O.A., Miah M.K., Venkataramanan R