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Given our in vitro evidence that LCN2 promotes osteocyte ferroptosis, we next examined whether Lcn2 ablation in osteocytes alters expression of ferroptosis-related genes (FRGs) in vivo

The role of DNA mismatch repair in drug resistance

Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility

These include various cellular processes and can modify or inhibit the enzymes involved in supporting processes 12,13,14

To verify that the SAT1 disruption cassettes were successfully excised from GDH2/gdh2 and GDH3/gdh3 strains, genomic PCR was used with primers C1 and C4 to amplify the region between the upper end of 5 flank sequences to the lower end of 3 flank sequences to make sure that both alleles of each gene were removed (Supplementary Fig