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J Hazard Mater 250:318332

330 (Pt 1), 175179

Notably, many effective antidiabetic drugs such as GLP-1, exenatide, and glitazones also show significant neuroprotective activity against glutamate-induced cytotoxicity in the brain [127, 128]

As a key component in cellular defense mechanisms, glutathione is essential for maintaining health and combating various diseases

Additionally, in-vivo studies have demonstrated an increase in toxicity of environmental pollutants, medicines, and allergens in Nrf2 deficient animals and an associated poorer response to plant chemicals such as PEITC (Reference 99) It is imperative to note however, that over-activation of Nrf2 activity in existing diseased cells can lead to resistance to radio- and chemotherapies presumably due to increased drug detoxification, and therefore is associated with a poorer prognosis