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Consequently, acetyl-CoA is an important biological molecule to consider when evaluating the metabolic and energetic status of cells

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Carrington PE, Sandu C, Wei YF, Hill JM, Morisawa G, Huang T, Gavathiotis E, Wei Y and Werner MH (2005) The three-dimensional structure of FADD defines the relative organization of death receptor and procaspase in the death-inducing signaling complex

This enables the removal of damaged and ROS-producing mitochondria by mitophagy, overall resulting in significant protection of mice from APAP-induced liver damage

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303 Mitochondrial dysfunction and diseases Note that the role of mitochondria in oxidative stress, inflammation, and aging has been discussed, it is important to recognize how mitochondrial dysfunction contributes to disease through the mechanisms outlined above