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Accordingly, Viardot et al

The functional moieties of Cur and eumelanin, when combined, work cooperatively to increase the effectiveness of AMEC at the targeted site

In NSCLC, EMT-associated genes, including E and N-cadherins, are regulated by alpha-enolase (ENO1), a key glycolytic enzyme, whose expression is increased in NSCLC tissues compared to normal ones, thus favoring glycolysis