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Splitting into twice-daily injections is reasonable at higher daily totals (e.g., 250 mcg AM + 250 mcg PM at a 500 mcg/day total)

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The water maze thus seems to be ideally suited to their behavioural analysis, when suitably modified, as it provides a bounded domain with easily controllable factors, and yet provides a complex problem: that of integrating spatial memory with suitable motor responses after having to learn both the generalities of the type of the domain, and the specific instantiation of the maze in any given trial

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2014 (PMID 25187433), which tied the procognitive effect to HGF/c-Met dependence, was retracted in 2025 (retraction notice PMID 40312093)