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Furthermore, Ataxia Telangiectasia Mutated-null chronic lymphocytic leukemia cells contained lower levels of antioxidants and elevated mitochondrial reactive oxygen species

[71] [72] [73] Recent epidemiological findings support the process of mitohormesis, but a 2007 meta-analysis finds that in studies with a low risk of bias (randomization, blinding, follow-up), some popular antioxidant supplements (vitamin A, beta carotene, and vitamin E) may increase mortality risk (although studies more prone to bias reported the reverse)

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Whilst anaemia typically resolves with B12 replacement, neurological damage may be permanent if deficiency remains untreated for extended periods

The reason for this is that any Glyteine inside cells is immediately converted to glutathione

Nevertheless, ongoing surveillance and research are important to fully characterize long-term safety as use of this therapy expands