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Protective effect of fenofibrate on oxidative stress-induced apoptosis in retinal-choroidal vascular endothelial cells: implication for diabetic retinopathy treatment

doi: 10.1016/j.freeradbiomed.2019.01.016 247 SchmittB.VicenziM.GarrelC.DenisF

According to mechanistic research, SLC7A11 and GPX4 stop ferroptosis by boosting cells antioxidant potential and preventing lipid peroxidation (107)

A simplified form of the reaction follows: Equation 2: X-Z + GS- GS-X + Z- Pumps that recognize the glutathione conjugated with a xenobiotic (Figure 21) (GS-X) have been described in animal plasmamembranes and plant tonoplast membranes