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Taken together, this evidence suggests that gut microbiota plays a key role in BD

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Moreover, it could have perhaps diminished the activity of urea cycle enzymes, reestablished nitrogen equilibrium, and maybe adjusted or enhanced the nitrogen levels in organs

Wu T, Song HY, Ji G

El-Mahdy MA, Ewees MG, Eid MS, Mahgoup EM, Khaleel SA, Zweier JL (2022) Electronic cigarette exposure causes vascular endothelial dysfunction due to NADPH oxidase activation and eNOS uncoupling