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Mechanistically, dual inhibition of protein kinase B (AKT) and extracellular-signal-regulated kinase (ERK)1/2 pathways can reduce E2 biosynthesis and restore specific PRB signaling of endometrial cells (28)

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These commenters referenced the benefits of these minimally invasive, in-office procedures, which eliminate the risks associated with general anesthesia and offer quicker recovery, fewer infections, and improved access to care

doi: 10.1016/j.joca.2020.02.103 21

According to eq 1, the modulation of effective half-life ( t half_eff ) is an important aspect of optimizing dose since the changes in t half_eff exponentially change the predicted dose, while the changes in all other parameters result in linear changes