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PD-1/PD-L1 checkpoint-blocking antibodies are thought to act primarily in the tumor microenvironment, where PD-L1 is expressed by tumor cells (174), myeloid cells (168, 203, 204), LECs (94, 95, 98), blood endothelial cells (95), B cells (205, 206), T cells (207), dendritic cells (203) and NK cells (208, 209)

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Creating a more nuanced understanding of its impact, at a public health and economic level, will be important for developing public policy around cost-effective and evidence-based