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Richards, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Alzheimers disease (AD) is a neurodegenerative disease characterized by extracellular plaques of -amyloid (A) and intracellular neurofibrillary tangles of tau protein and is the main cause of dementia (90)

Metabolomic studies on patients with PKU have demonstrated elevated serum levels of phenylalanine derivatives, including phenylpyruvate, phenylacetate, phenyllactate, mandelic acid, 4-hydroxyphenylacetic acid, and several others (54, 55)

Gonzalez et al

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The origin of TML in the E