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Exogenous glucocorticoids (synthetic or natural) are used to treat diseases caused by an overactive immune system (e.g

A: Mechanism driven by p53 mutation

In streptozotocin-induced diabetic rats, which have reduced plasma carnitine and IGF-1 concentrations compared with normal rats, supplementation of 50, 100 or 200 mg l-carnitine per kg diet also caused a dose-dependent increase in plasma IGF-1 concentration ( Reference Heo, Kang and Cha 65 )

Transfer of calcium ions from the stressed ER to mitochondria could trigger apoptosis and subsequent release of abundant mitochondrial ROS to the cytoplasm 12,18