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And though no ongoing trials target specific genes identified in screening studies, several clinical investigations implicate genetic dependencies identified in genetic screens

The possible mechanism of drug delivery into the fundus through NEs as eye drops may be a noncorneal pathway, that is, by means of the sclera, which has higher permeability, a higher surface area, and easier accessibility

Neurol Clin Neurosci 9:1016

Identification of a functional antioxidant response element at the HIF1A locus

Dihydroartemisinin (DHA) exemplifies this duality: at low concentrations or under specific conditions, DHA can paradoxically increase GPX4 activity by upregulating ATF4 expression, potentially suppressing ferroptosis

The anti-CD38 phycoerythrin (PE) and anti-CD138 fluorescein isothiocyanate (FITC) antibodies, and APO-DIRECT kit (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)) were purchased from BD Biosciences (San Jose, CA, USA)