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The kinase activity of nuclear IGF-1R is also implicated in the phosphorylation of histone H3, recruitment of the ATP-dependent helicase Brg1 and the expression of SNAI2 [118], which in turn is involved in cell migration and epithelial-mesenchymal transformation

doi: 10.1016/j.jtemb.2013.12.005, 205

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Brain Res Rev 67:157183

Understanding Hyperpigmentation and Its Causes Hyperpigmentation represents one of the most common skin concerns affecting individuals worldwide, manifesting as dark patches, spots, or uneven skin tone that can significantly impact confidence and appearance