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10.31083/j.rcm230517839077615 204 Chen Y, Wu Y, Chu X, et al

For example, by decreasing the affinity of a T cell receptor for an antigen (which a TCR binds in conjunction with an MHC molecule, i.e., the MHC "presents" the antigen to the TCR), the methods of the invention can generate a non-autoreactive variant of an autoreactive TCR