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Salinas et al 27 The traditional treatment of vitamin B 12 deficiency is the intramuscular injection of cyanocobalamin, generally, 1 mg/d for 1 week, followed by 1 mg/wk for 1 month, and then 1 mg every 1 or2 months ad perpetuum

Compounded medications such as MIC + B12 are not FDA approved

PMID: 22261807

As a result, researchers can obtain materials that align with documented quality standards and analytical requirements

The question is whether that systemic dose is sufficient to have a meaningful impact on a peripheral joint like the knee compared to a direct subcutaneous injection