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10.1016/j.freeradbiomed.2022.08.043 358 TebarF.BohlanderS

The other reason is due to decreased uridine diphosphate glucuronosyltransferase activity in liver cells which results in decreased bilirubin conjugation in the liver

In particular, GSTT1-1 and GSTM1-1 null genotypes, as well as GSTP1-1 variants, were studies and showed a positive correlation with cancer risk (Table 1) 24,32,35,36,37,38,39,40,41,42

In humans, glutathione is predominantly an intracellular compound, with cytosolic concentrations in the millimolar range and with extracellular and plasma concentrations three orders of magnitude lower, ie, 1 M to 3 M (49

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While the cells treated with Ru(II)-OH or NP2 in a 1% O 2 atmosphere were confluent and alive, the cell treated with NP4 had a strongly reduced cell population and a mixture of living and dead cells comparable to the treatment with these nanoparticles in a 21% O 2 atmosphere (Fig