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10.1016/j.bbrc.2022.10.065 127 YeZ.LiuW.ZhuoQ.HuQ.LiuM.SunQ.et al (2020)

We inhale toxins through the air we breathe, absorb them through our skin when we use personal care products, and ingest them when we eat foods that have been steeped in pesticides

Notably, in models of type 2 diabetes, PCs confer neuroprotection by modulating NF-E2/STAT1 signaling, attenuating Janus kinase activity, and inhibiting cell apoptosis, thereby reducing cerebrovascular lesions and associated neurological deficits (Wu et al., 2015

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CDNF exerts effects through direct binding to unfolded protein response (UPR) sensors PERK and IRE1, while its family member MANF primarily signals via IRE1 [81]