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The capsule shell can provide a relatively stable environment, extend the shelf life of drugs, and ensure that drugs can exert stable therapeutic effects within their effective period

Interestingly, infants with congenital GH deficiency and GHR mutations present with only minor growth retardation, whereas the rare patient with IGF-I deficiency, secondary to a homozygous partial deletion of the IGF-I gene, presents with severe pre and postnatal growth failure, mental retardation, sensorineural deafness, and microcephaly (76-78)

The Vitamin B12 Test is important in differentiating between various types of anemia

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