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A recent experiment showed that blocking the IL-4/IL-13 pathway alleviates glucocorticoid-dependent severe asthma, moderate-to-severe uncontrolled asthma and AD

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The large localized production of superoxide will form a major sink to trap NO produced by any cell in the region and the peroxynitrite will react quickly in the immediate region because of the large local concentrations of carbon dioxide produced by activation of the hexose monophosphate shunt activated to supply NADPH needed for superoxide formation and NO synthesis

However, new insight into glutathione synthesis and metabolism in the latter group necessitates reconsideration of its status and role in LAB and Gram positive bacteria in general

Competing interests The authors declare that they have any competing interests in this article