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For instance, a pilot clinical trial involving individuals with knee osteoarthritis demonstrated that taking MSM contributed to a significant reduction in pain and improved physical function over a 12-week period compared to a placebo.(4) Another randomized controlled study supported these findings, showing that patients with knee OA who took MSM for 12 weeks experienced small but significant improvements in physical function and total symptom scores, though the clinical significance of these findings requires further investigation.(5) MSM has also been shown to help preserve cartilage and support the effectiveness of glucosamine and chondroitin, other key compounds found in cartilage and connective tissue.(1) With that said, MSM is not a replacement for proper medical diagnosis

Li X, Guo Y, Huang S, He M, Liu Q, Chen W, et al

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Glutamine, a copious nonessential amino acid in the cellular environment, plays a fundamental role in diverse biological processes, including protein synthesis, immune modulation and cellular metabolism (138)

Figure 1 4.1 Impaired intestinal barrier and leaky gut The exact pathogenesis of ITP remains unclear, but increasing evidence suggests that gut barrier damage and leaky gut production may be an important factor (Usuda et al., 2021

Jacob, J