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Dai, L., et al., Novel Multiarm Polyethylene glycol-Dihydroartemisinin Conjugates Enhancing Therapeutic Efficacy in Non-Small-Cell Lung Cancer

Research indicates that oxidative damage in the retina induced by hyperglycemia is mediated through four key metabolic disturbances: activation of the protein kinase C (PKC) pathway, flux through the polyol pathway, activation of the hexosamine pathway, and intracellular formation of advanced glycation end products (AGEs) (4)