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Disruption of this adaptive ROS homeostasis further induces pathological manifestations

However, some studies suggest that GCase deficiency impacts degradation differently depending on model-specific conditions [218]

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(77) observed that the non-classical effector proteins Caspase-4/-5/-11 could regulate the tetrapeptide sequence identity of IL-1 and IL-18, thereby modulating IL-1 and IL-18 recruitment and activation, which provides a basis for the development of new therapies for related diseases

Goedert M, Hasegawa M, Jakes R, Lawler S, Cuenda A, Cohen P