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FIGURE 1 Perceived Stress Scale 10 scores were significantly higher in women than in men ( t 175 = 2.59, p = 0.01)

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Meanwhile, the activity of nicotinamide adenine dinucleotide (NAD + )-dependent deacetylases Sirtuins [especially sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3)] decreases due to NAD + depletion, leading to hyperacetylation of multiple target proteins, which tends to enhance NF-B signaling and inhibit fatty acid oxidation (52, 53)

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A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people

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