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In addition, histochemical studies performed by auto-metallography [178,179,180] show that in some organs metals can accumulate as sub-micrometre sized particles of elemental gold [181] and silver [178,182], of the sulphides of mercury [183,184,185,186,187,188] and of bismuth [180,189]

Indeed, high plasma level of TNF- is associated with a marked increase in CRP and IL-6, suggesting an interrelated stimulation of the entire inflammatory cascade (Xia et al., 2016)

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Other peptides that the body makes include insulin, substance P, neuropeptide Y, ghrelin, CCK, leptin, leuteinizing hormone, thyroid-stimulating hormone, and more