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Macrophages, particularly Kupffer cells, are major producers of TNF in MASLD/MASH, and macrophage-derived TNF contributes to progression from steatosis to steatohepatitis and fibrotic liver injury (125, 126)

Symptoms of Osteoporotic Spinal Fractures Symptoms of Vertebral Fracture Spine deformity results in a forward bent posture Reduced diameter of vertebral bodies decreases body height Static changes of the spine impairs mobility and balance Reduced height impairs lung capacity, breathing, and leads to a deterioration in general metabolism Increased pressure in internal organs resulting from spinal deformity Potential for neurological impairment (palsy, numbness, loss of strength, impaired reflexes) due to increased pressure on spinal cord and nerve roots In healthy patients a vertebral fracture can occur as a rare consequence of a serious accident

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Diabetologia 21 , 464469 (1981)

Data ( ce ) pooled from four independent experiments (untreated n = 16

Candida albicans biofilms and human disease