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(8R)-4, 5 dihydroxy-8 hydroxymethyl-3-methoxy deoxybenzoin, methyl chlorogenic acid, hydroquinone and cresol were further obtained by ultrasonic-assisted extraction of the active metabolites in Ficus hirta Vahl and determination using high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS)

In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing

Han YH, Kim SH, Kim SZ, Park WH

In malignant proliferating cells dominated by glycolysis, the upregulation of glutamine metabolism promotes energy metabolism via the modulation of TCA cycle and provides raw materials for lipid and amino acid delivery as well as biosynthesis of purines and pyrimidines, which ultimately promotes tumor growth by facilitating cell proliferation and inhibiting cell apoptosis (31, 32)

Thus, studies conducted on animals have demonstrated that inhibition of the endogenous methylation demand by creatine supplementation can reduce Hcy levels, but these results have not been reproduced in human subjects

doi: 167