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More recently, riluzole has been shown to potentiate reuptake of extrasynaptic glutamate by glial cells (Frizzo, Dall'Onder, Dalcin, & Souza, 2004

doi:10.1016/S0006-3495(96)79835-1 91

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53,57,58 A meta-analysis of six randomized controlled trials with a total of 355 participants found myo-inositol was comparable to metformin with regard to its effects on fasting insulin and insulin sensitivity, testosterone, sex hormone binding globulin (SHBG), and body mass index (BMI) (a measure of body weight status) in women with PCOS, while metformin treatment carried a higher risk of adverse effects

Non-negotiable targets: Protein: 80-100g daily minimum (prevents muscle loss during weight loss) Calories: Dont go below 1,200 (women) or 1,500 (men) despite suppressed appetite Fiber: 25-35g daily (prevents constipation, supports gut health) Healthy fats: 30-50g daily (prevents gallbladder issues during rapid weight loss) Meal structure moving forward: Still smaller frequent meals (5-6 per day)

doi: 10.1186/s13567-021-00948-4 105 KratschmerCLevyM