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The rescue effects of these agonists were specifically reversed by their corresponding inhibitors, SKF96365, HC067047, GsMTx-4 and Pyr3, further supporting the involvement of these channels in mediating the Ca 2+ signal downstream of XKR8 (Fig

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It has shown good efficacy in the treatment of malignant tumours, such as prostate cancer, breast cancer, and chronic lymphocytic leukaemia [129]

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Acute neurotoxicity occurs within hours of administration, triggered by cold exposure, manifesting as transient paresthesia/numbness in the extremities, perioral region and throat, often with muscle or laryngospasm