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Other reported NRF2 agonists with potential AD-modifying effects include flavonoids (eriodictyol), polyphenols (tannic acid), terpenoids (ginkgolide B), and lignans (forsythiaside A) (324327) ( Figure 7 )

Upon extracellular stimulation, multiple serine-threonine residues within the carboxy-terminal are sequentially phosphorylated leading to conformational changes allowing the SH3 and PX domains to interact with the proline-rich region of the p22 phox and PtdIns(3,4) P 2 , respectively (Ago et al., 1999