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Some studies cited in a 2025 review noted that while proline can protect cells at low levels, when metabolized by the enzyme proline oxidase it produces reactive oxygen species (ROS)

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The strategic implication for brand companies is the mirror image: carefully drafted method-of-use patent claims, combined with patents timed to cover the highest-revenue indication, can force any skinny-label generic into the lowest-value segment of the market even when the drug substance patent has expired

Glutathione is present in the body both in reduced form as GSH and in oxidized form as GSSG (glutathione disulfide)

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