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Congested (i.e., inferior caval vein and superior mesenteric vein) and failed (azygos vein) blood vessels, multiple organs lesions, heart, lung, liver, kidney, the gastrointestinal tract in particular, and muscle weakness, as well as brain lesions, eye lesions (increased intraocular pressure, retinal ischemia) and oxidative stress in tissues were markedly attenuated [14,15,16,19,20,21,22,23,24,25]

The resemblance of telomeres with DNA breaks requires the suppression of several DNA damage response (DDR) pathways that otherwise target double-strand (ds) DNA breaks and ssDNA, which make telomeres particularly susceptible to erroneous activation of the DDR and cell cycle arrest 4

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Pathogens 11(6):692 Lee NK, Park YS, Kang DK, Paik HD (2023) Paraprobiotics: definition, manufacturing methods, and functionality

[DOI] [PubMed] [Google Scholar] 51.Shimokawa T., Smith W.L

Notably, so-called NRF2 activators primarily function as inhibitors of Keap1, the cytoplasmic repressor that targets NRF2 for proteasomal degradation (Magesh et al., 2012)