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Nat Commun (2022) 131(13):115

It is likely that a redox reaction between reduced ascorbic acid and hematin generates free radicals, which in turn leads to the degradation of the porphyrin ring

In addition to this proteinprotein interaction, Thi2.4 exhibits direct antifungal activity by disrupting fungal cell membranes ( 2.1.3.3 Insect and nematode resistance In barley ( Hordeum vulgare ), the thionin genes THIO1567 and THIO1570 exhibited significantly higher transcript levels in the bird cherryoat aphid ( Rhopalosiphum padi L.)-resistant genotype Hsp5 compared to the susceptible genotype Lina, suggesting a role in aphid resistance (Mehrabi et al., 2014)

Yalin SS, Yurdakk K, Yalin S, Engr-Karasimav D, Cokun T

Although lipoxygenases do not have extensive regulatory effects on ferroptosis, they play essential roles in specific ferroptosis mechanisms

This network logic explains why blocking one arm can blunt PANoptotic and necroptotic spread, whereas autophagy failure primes multiple death programs simultaneously