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demonstrated through comparative experiments that DHI significantly increases lipid peroxidation levels and inhibits GSH, leading to a decrease in the GSH/GSSG ratio and weakened cellular antioxidant capacity, further resulting in the loss of GPX4 activity

NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR): possible dietary contribution to health

In doing so, the glutathione molecule itself becomes a reactive thiyl radical, which quickly pairs with another oxidized glutathione molecule to form glutathione disulfide (GSSG)

Glutathione is one of the most powerful antioxidants in the body as it is the only one that is intracellular

Conversely, KEAP1 mutations lead to constitutive NRF2 activation, driving ferroptosis resistance (Scalera et al