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A retrospective study of anemia in 456 dogs (excluding those with acute blood loss anemia) showed that the most frequent causes of anemia were inflammatory disease and cancer-associated anemia (which could be multifactorial in origin and the cohort could have included cases with splenic tumor-related hemoperitoneum), which comprised 62% of the total cases, followed by immune-mediated hemolytic anemia (IMHA, 13% of cases)

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In addition, many other mechanisms regulating ferroptosis have been revealed, such as the AMPK-mediated anti-ferroptotic effect of energy stress[97] and glutamate-cysteine ligase catalytic subunit (GCLC)-conferred protection against ferroptosis mediated by its contribution to maintaining glutamate homeostasis[86]

Exercise-induced oxidative stress and the effects of antioxidant intake from a physiological viewpoint

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Its molecular structure allows it to span the entire width of a cell membrane anchoring at both the inner and outer surface