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Endocrinology 128 , 779785 (1991)

Part of the problem may stem from the multifacetedness of MdDS symptomatology and disconnection from objective means to gauge the severity of symptoms that are only subjectively experienced by patients (23)

58 HTS performed by Vertex Pharmaceutical with the support of the Cystic Fibrosis Foundation Therapeutics, identified the correctors VX-809 and more recently, VX-661 (refs 57, 59)