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Gish Consultants, LLC, San Diego, California, USA Background: Obeticholic acid (OCA) is approved for second-line (2L) therapy in patients with primary biliary cholangitis (PBC) who have inadequate response or intolerance to ursodeoxycholic acid (UDCA)

Chen PY, Yen JC, Liu TT, Chen ST, Wang SJ, Chen SP (2023) Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation

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However, it is important to note that there is insufficient data on safety or side effects in humans, and these peptides remain strictly for laboratory research purposes only