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Its safety profile in early human trials appears good, though long-term data are limited

In the case of long sleep duration causing T2DM, sleep can still occur despite sleep fragmentation, frequent awakenings, and poor sleep quality [106], which are indicative of poor metabolic health caused by low physical activity, depression, or obesity [107]

In addition, the plasma syndecan-1 concentration of septic mice is reduced by recombinant thrombomodulin, suggesting that it ameliorates glycocalyx injury (130)

10.1007/s10741-007-9041-2 148 UchihashiM.HoshinoA.OkawaY.AriyoshiM.KaimotoS.TateishiS.et al (2017)

doi: 10.1146/annurev-immunol-020711-074934 160 BibbyJAPurvisHAHaydayTChandraAOkkenhaugKRosenzweigSet al

3gss: AJ Oakley, J Rossjohn, M Lo Bello, AM Caccuri, G Federici & MW Parker (1997) The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate