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2020;217(10): e20200359

Older adults are at a higher risk for B12 deficiency for a number of reasons: Digestive issues that interfere with absorption Reduced food intake Dental issues that discourage meat consumption Disturbances to the gut biome Excess alcohol consumption Reduced stomach acid production that lowers absorption Reduced consumption and absorption of B12 can lead to neurological disorders, cognitive impairment and a number of other issues that accelerate aging and reduce overall quality of life

In an initial pilot study using high throughput proteomics applications on plasma samples collected from 29 affected children and 31 unrelated and unaffected children in 2011, we identified several proteins of interest that showed statistical differences between the groups

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