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23 NADPH is also needed for dihydrofolate reductase (DHFR) enzyme to catalyze the reduction of dihydrofolate to tetrahydrofolate (THF) in folate metabolism, which is required for de novo biosynthesis of thymidylate, purines, methionine, and some amino acids

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Figure 3 4.3 Tumor antigens of MB The antigen-specific immune response could be considered one of the cellular-mediated mechanisms by which MB cells can be eliminated