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Given these results, we consider these loop-5 residues to be essential for substrate binding

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Recent studies suggest that increasing NAD+ levels can enhance cognitive function and reduce pathological markers associated with Alzheimers disease

Several other studies point towards a crucial role for D2 (and D3, see below) in regulating local T3 concentrations, and as a consequence it is know well accepted that these deiodinases can regulate thyroid hormone action at the cellular level during development and tissue stress relatively independent of serum T4 and T3 concentrations (3)

J Biol Chem 277: 1891418918 Yun CW, Ferea T, Rashford J, Ardon O, Brown PO, Botstein D, Kaplan J, Philpott CC (2000) Desferrioxaminemediated iron uptake in Saccharomyces cerevisiae