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Inflammation-driven patients: Reduced morning stiffness and overall systemic feels better response within 3 to 5 weeks in most cases

Multiple rodent studies have demonstrated that BPC 157 administration both locally and systemically reduces markers of gastric damage, accelerates mucosal healing in ulcer models, and appears to counteract the damage caused by NSAIDs and corticosteroids

It has also been investigated for alleviating neuropathic pain by improving nerve function and regeneration

) And then theres the even more striking parallel with arginine, another non-essential amino acid with a variety of functions whose supplementation causes benefits in laboratory animals, and even a suggestion of cardiovascular benefits in short-term human studiesincluding improving artery function just like taurine

In a further embodiment, the following are encompassed by the present invention: a method for identifying a mutant of MMP-29 with altered biological properties, function, or reactivity, the method comprising any combination of steps of: use of the MMP-29 propeptide domain, catalytic domain, and/or hemopexin-like domain models or a homologue of said models according to Tables IV, V, and/or VI, for the design of protein mutants with altered biological function or properties which exhibit any combination of therapeutic effects provided elsewhere herein

Acta Pharm Sin 2020;41:158796