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Common Contraindications Active or recent cancer (BPC-157 and TB-500 angiogenesis concern), Wilson's disease or other copper metabolism disorders (GHK-Cu component), pregnancy or breastfeeding (no safety data for any component), and competitive sport at WADA-tested levels (BPC-157 and TB-500 are listed under WADA category S0 Unapproved Substances) are commonly cited reasons not to research KLOW

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Alleviation of A-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model

Over recent years two trials with nerve growth factor (NGF) designed to protect forebrain cholinergic neurons (early to moderate stage AD patients) were terminated after phase I [15,16] (NCT00017940, NCT00876863)

2 2) Modulation of the nitric-oxide (NO) system & vascular tone Ex vivo aorta studies show BPC-157 modulates vasomotor tone in an NO-dependent manner, likely via SrcCav-1eNOS interactions that increase NO generation