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In musculatura striata (cea scheletica, responsabila de miscarea organismului) si in muschiul cardiac, o contributie majora la productia de energie o are oxidarea acizilor grasi

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Under normal conditions, ROS generation is balanced with antioxidant mechanisms, known as free radical scavengers. Antioxidant enzymes include both superoxide dismutase (as implicated in SOD1 ALS), which detoxicates superoxide into the less reactive hydrogen peroxide, and peroxisomal enzymes, which then reduce hydrogen peroxide to water [278]